Rare coding variants point to 13 genes in bipolar disorder
Thirteen genes reach exome-wide significance for bipolar disorder in a medRxiv preprint posted October 5. The authors analyzed sequencing data from 64,435 people with the disorder and 168,101 controls, 232,536 in all, from 22 countries and multiple ancestries. Protein-truncating and damaging missense variants were enriched in constrained genes and curated neuropsychiatric gene sets, and the signals held across ancestry groups. The genes were preferentially expressed in the brain, with expression rising in early childhood. In DOP1A and ATP9A, ultra-rare missense variants clustered at predicted interaction interfaces.
Researchers studying bipolar disorder now have 13 genes to follow up. The work is a preprint and has not been peer reviewed.
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