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199 stories. Landmark developments from the last eight years sit alongside the daily desk; every entry links its primary source.

2026

October 6, 2026Do natural redheads really need more anesthesia? How surgical trials, 1,000 Genomes, and pain panels detangled the mythpharmacogenomics
October 5, 2026Genome sequencing diagnosed more developmental disorders in a Belgian trial
October 5, 2026Whole-genome sequencing finds hereditary cancer variants in Northeast Brazil
October 5, 2026Avian R2 retrotransposons used to insert DNA at set sites in human cells
October 4, 2026Lung cancer trial of CCL21 dendritic cell vaccine plus pembrolizumab sees no objective responses
October 3, 2026ADAMTS6 loss of function linked to a new connective tissue disorder
October 2, 2026Urine RNA test detects bladder cancer and predicts BCG response
October 2, 2026New chromatin mapping method links autoimmune risk variant to SESN3 gene
October 2, 2026Urine RNA test flags localized bladder cancer at 95% sensitivity
October 1, 2026Editing silencer elements reactivates embryonic ζ-globin in α-thalassemia models
October 1, 2026Reactivating embryonic ζ-globin rescues mouse model of severe α-thalassemia
October 1, 2026Free tests and direct contact raised cascade genetic testing among relatives, trial finds
October 1, 2026Patient-derived teratomas tested for dystrophin restoration in Duchenne muscular dystrophy
October 1, 2026Human, chimpanzee and bonobo genomes share an ancient population size peak
September 30, 2026Genetic study links BACH2 and NRF2 to fetal haemoglobin activation
September 30, 2026Genetic study implicates BACH2-NRF2 axis in fetal haemoglobin activation
September 30, 2026Oncolytic adenovirus VCN-01 added to chemotherapy lengthens progression-free survival in metastatic pancreatic cancer
September 30, 2026Alternative polyadenylation mapped across 2 million cells in 379 human brains
September 29, 2026Structural variants explain 8 percent of plasma protein heritability in 54,306 UK Biobank participants
September 29, 2026Werner helicase inhibitor RO7589831 produces partial responses in 7 of 66 MSI patients
September 29, 2026Single-cell atlas of 77 liver disease patients pinpoints pro-fibrotic macrophage target
September 28, 2026Reanalysis of genome data doubles rare disease diagnoses for Welsh patients
September 28, 2026Individualized reanalysis diagnoses 40 percent of patients left undiagnosed by exome or genome tests
September 28, 2026Single-cell atlas of 77 livers points to OLR1 macrophages in fibrosis
September 28, 2026Solid-state mRNA vaccines hold 100% bioactivity at 37 °C in animal work
September 27, 2026Polygenic scores improved prediction most for metabolic and heart disease
September 25, 2026Genetic testing panel finds cancer predisposition diagnoses in nearly half of unresolved pediatric cases
September 25, 2026Euchromatin folds into dense clumps, not open strands, study finds
September 24, 2026Admixture mapping turns up 48 disease links that GWAS missed in biobank study
September 24, 2026KDM2B enzyme found essential in aggressive medulloblastoma subtypes
September 23, 2026Single-cell brain atlas maps gene regulation across 1,384 donors
September 23, 2026Studies in Nature map prefrontal cortex cells from nearly 1,500 people
September 23, 2026Gene regulatory changes shaped human skeleton, study finds
September 23, 2026Single-nucleus prefrontal cortex atlas links genetic risk to cell types across ancestries
September 23, 2026Graph neural network ties single-cell brain data to Alzheimer's disease traits
September 23, 2026Human gene-regulation map ties cartilage changes to joint disease risk
September 22, 2026Blood test maps targetable mutations in 12,827 metastatic breast cancer patients
September 21, 2026Epigenetic editing silences hepatitis B virus in liver cells and mice
September 21, 2026Newborn genomic screening in over 10,800 babies finds positive rates up to 3.7 percent
September 21, 2026Exome, genome sequencing matched microarray for copy number variant detection
September 18, 2026Man with rare motor neuron disease improves on first RNA drug aimed at his mutation
September 18, 2026FDA approves first gene therapy for Sanfilippo syndrome type A
September 16, 2026ESHG and ISPD issue global guidance on prenatal genomic sequencing
September 16, 2026Gene therapy appears safe in adolescents with hemophilia B
September 16, 2026Prime assembly integrates DNA sequences into human cells without double-strand breaks
September 16, 2026AAV gene therapy lowers bleeding rate in adolescents with hemophilia B, trial finds
September 16, 2026FDA approves breast cancer drug tied to ESR1 mutation test
September 15, 2026Interferon-alpha pushes blood stem cells down two opposing paths in myeloproliferative neoplasms
September 15, 2026Oral KRAS G12D inhibitor GFH375 shows responses in pancreatic cancer
September 15, 2026Selective KRAS G12D inhibitors show early activity in advanced cancers
September 14, 2026Multiancestry biobank data sharpens polygenic risk scores for underrepresented groups
September 13, 2026Base editor repaired embryo lesions without indels, but mRNA delivery caused frequent arrest
September 11, 2026NIH workshop updates guidance on returning genomic findings to research participants
September 11, 2026Rare CNV burden tied to schizophrenia risk in East Asians, cross-population study finds
September 11, 2026Rare CNVs linked to schizophrenia risk in East Asian cohorts
September 10, 2026Our Future Health reports baseline data on 1.9 million UK participants
September 9, 2026New model uses species trees to predict variant effects across genomes
September 9, 2026GPN-Star model uses evolutionary trees to predict genetic variant effects
September 9, 2026Daily vosoritide injections boosted growth in hypochondroplasia trial
September 9, 2026Serum proteomics led to genetic diagnoses in 13 rare disease patients after genome sequencing came up empty
September 9, 2026Undiagnosed Diseases Network diagnoses 379 participants through data reanalysis and case matching
September 9, 2026FDA draft guidance sets framework for individualized rare disease therapies
September 8, 2026DeepMind releases atlas of 9 billion human gene mutations
September 8, 2026Method finds unknown hominin DNA in modern genomes without ancient reference sequences
September 8, 2026Diploid genome benchmark covers 99.4% of HG002 genome with phased haplotypes
September 7, 2026Heritable variant sequences within telomeres set allele-specific length
September 7, 2026Review examines programmable enzymes for large DNA insertion
September 7, 2026Multi-ancestry study links 236 MS risk variants to inhibitory neurons
September 5, 2026Mexican genome project sequences 1,481 individuals to map regional genetic variants
September 4, 2026Meta-analysis links 70 genetic loci to hypertrophic cardiomyopathy risk
September 3, 2026Genetic variants lowering lipoprotein(a) and LDL cholesterol together cut coronary artery disease risk
September 2, 2026Macrophages fuse distant gene transcripts to build immune proteins
September 2, 2026Study maps 315 genes tied to brain network connections
September 2, 2026Mayo Clinic records reveal five distinct metabolic liver disease subtypes
September 2, 2026Researchers find 1,200 genetic variants tied to personality in study of over a million people
September 2, 2026UniQure submits Huntington's gene therapy to FDA after agency reversal
September 2, 2026Engineered DNA sites boost targeted gene integration in rice and human cells
September 1, 2026Multiancestry polygenic risk score improves hypertrophic cardiomyopathy risk stratification
September 1, 2026Whole-exome sequencing identifies 36 risk genes for obsessive-compulsive disorder and chronic tic disorders
September 1, 2026Lineage barcodes track how lung tumors rewire their surroundings in mice
September 1, 2026OmicsPred platform shares genetic models for multi-omic trait prediction
September 1, 2026Giant Starship transposons drive horizontal gene transfer across fungal species
September 1, 2026Guide RNAs block reverse transcription and inflate CRISPR RNA knockdown measurements
September 1, 2026Single-cell atlas of myeloma defines five malignant archetypes
August 29, 2026New framework squeezes more accuracy from existing genetic risk models
August 29, 2026One-third of gene-protein links show nonlinear dose effects in UK Biobank analysis
August 28, 2026Cardiovascular disease heritability estimates differ across three US and UK biobanks
August 28, 2026New prime editing technique inserts DNA sequences up to 12.5 kilobases without breaking strands
August 28, 2026New prime editing method inserts DNA fragments up to 12.5 kilobases without double-strand breaks
August 28, 2026Prime assembly integrates DNA fragments up to 6.5 kb without viral vectors
August 27, 2026Dubai hospital scales rapid genome sequencing for critically ill children
August 27, 2026New tool inserts DNA fragments up to 6.5 kb into human cells
August 27, 2026Polygenic risk score for Alzheimer's performs across ancestry groups
August 26, 2026Cell-type-specific gene effects help explain complex trait heritability
August 26, 2026Sperm study finds gene conversion happens before meiosis
August 26, 2026Deletions at 22q11.21 raise Alzheimer risk in early-onset cases, exome study finds
August 26, 2026Machine learning tool trained on functional assays improves missense variant prediction
August 26, 2026Myotis bat genomes show linked evolution of longevity and viral defense
August 26, 2026FDA Approves First Gene-Targeted Drug for Advanced Pancreatic Cancer
August 25, 2026Pituitary Society Sets Standards for Genetic Testing in Pituitary Tumors
August 25, 2026RNA Splicing Tests Sharpen BRCA1 Variant Classification in 166-Variant Study
August 25, 2026Mutation Clearance After Induction Links to Longer Remission in Intermediate-Risk AML
August 25, 2026RNA sequencing framework IsoRanker finds disease-causing variants missed by standard genome analysis
August 24, 2026Dubai ICU Program Diagnoses 53 Percent of Critically Ill Children Using Rapid Genome Sequencing
August 24, 2026FDA halts Regenxbio gene therapy trial after spinal masses found in five patients
August 24, 2026Dubai ICU program cuts genetic diagnosis time to 3.4 days for critically ill children
August 24, 2026New protein engineering strategy optimizes compact genome editors with limited data
August 23, 2026Machine Learning Decodes DNA Initiator Pattern Present in 60 Percent of Human Genes
August 23, 2026New protein engineering method yields compact genome editor with 97 percent peak efficiency
August 22, 2026Prenatal Screen for Rare Chromosome Abnormalities Confirms Fetal Diagnosis in Only 5 Percent of Positive Cases
August 21, 2026Study finds rare facial syndromes follow same genetic patterns as normal variation
August 20, 2026Sixteen epigenetic aging clocks evaluated across fifty one human intervention studies
August 20, 2026Multiomic atlas maps stalled neurogenesis in adult hippocampus of depressed patients
August 20, 2026FDA approves gene therapy for rare metabolic disease, Regeneron drug for bone disorder
August 20, 2026Most people carry genetic variants that raise drug reaction risk, health records show
August 20, 2026Rotifer study links maternal age effects to epigenetics
August 19, 2026New Method Assigns Probabilities Across Multiple Psychiatric Diagnoses
August 19, 2026New method makes over 1,000 gene fragments in one shot
August 18, 2026Dongguk team builds electromagnetic gene expression switch
August 15, 2026Engineered bacteria bioleach olivine and store carbon as oxalate
August 15, 2026Screen finds RNA elements that stabilize modified mRNA
August 14, 2026Phage genomes carry mutable regions that hedge against defenses
August 13, 2026Losing one TBX5 copy disrupts 3D DNA folding in heart cells
April 23, 2026GeneReviews Updates Alpha-Thalassemia Clinical Guide
February 12, 2026GeneReviews updates spinal muscular atrophy diagnosis and treatment guidance

2025

November 20, 2025NCBI updates clinical guidance for phenylalanine hydroxylase deficiencygenomes
September 18, 2025UK Biobank expands genetic analysis to diverse ancestry groups
February 17, 2025New complete human genome reveals 51 megabases of hidden Neanderthal DNA

2024

December 13, 2024Neanderthal gene flow traced to single 7,000-year window
October 4, 2024NHS will sequence genomes of 100,000 newborns in Englandnewborn screening
July 19, 2024VA Million Veteran Program finds 13,672 genomic risk loci across 2,068 traits in diverse cohort
July 12, 2024Neanderthals carried up to 3.7 percent modern human DNA from two separate waves of interbreeding
May 16, 2024GeneReviews Updates FMR1 Disorder Guidelines
May 8, 2024AlphaFold 3 architecture described in Nature paperai biology
February 19, 2024All of Us releases genome sequences for 245,388 participantspopulation genomics

2023

December 8, 2023FDA approves Casgevy and Lyfgenia for sickle cell diseasecrispr
December 7, 2023NCBI updates Gaucher disease clinical referencegenomes
November 28, 2023Korean study links ADRB2 gene variant to elite athletic performancegenomes
November 16, 2023MHRA authorises Casgevy, world-first CRISPR gene therapy, for sickle-cell disease and beta-thalassemiacrispr
September 17, 2023Neanderthal genes shifted modern humans toward morning wakefulnessgenomes
June 22, 2023FDA Clears First Gene Therapy for Young Duchenne Patientsgene therapy
May 10, 2023Draft human pangenome reference publishedreference genome
April 27, 2023GeneReviews updates clinical overview of acid sphingomyelinase deficiencygenomes
January 24, 2023Rage at eating sounds shares genetic links with anxiety and PTSDgenomes
January 18, 2023FinnGen study finds 30 new disease associations in Finnish population
January 1, 2023GWAS Catalog adds sequencing data, links to Polygenic Score Catalog

2022

October 19, 2022Nature study finds father-daughter pair among 13 Siberian Neanderthalsancient dna
October 3, 2022Svante Pääbo Wins 2022 Nobel Prize for Sequencing Extinct Hominin Genomesancient dna
September 14, 2022Unsampled ghost lineages can invalidate phylogenetic findings on horizontal gene flow
July 1, 2022Common gene variants change how a rare cleft palate mutation plays out
March 31, 2022Scientists finish first gapless sequence of a human genomereference genome
March 24, 2022Stanford Team Builds 813 Polygenic Risk Scores from UK Biobank Data
March 11, 2022Pharmacogenetics consortium updates statin dosing guideline to account for three genesgenomes
January 1, 2022Polygenic scores lose accuracy fast across UK Biobank ancestry groups

2021

November 4, 2021Diabetes subtypes traced to different genetic drivers
October 18, 2021Review Maps Tools to Study Transposons in Ancient Human DNA
October 1, 2021Genetic risk score tracked melanoma cases in older ASPREE trial group
July 20, 2021ACMG publishes carrier screening guidance for pregnancy, preconceptioncarrier screening
July 16, 2021New algorithm maps human genome, finds only 1.5 to 7 percent is uniquely human
July 15, 2021AlphaFold predicts protein structures with atomic accuracy in CASP14 testai biology
June 12, 2021Immune gene mismatches between partners may boost sperm survival
May 19, 2021Base editing cuts cholesterol in monkeys, Nature study findscrispr
May 19, 2021New Protocol Details How to Find Neanderthal and Denisovan DNA in Living Humansgenomes
April 14, 2021MTAP Staining Confirms Gene Deletion in Mesothelioma, but Normal Expression Does Not Rule It Outgenomes
March 9, 2021Study across five ancestries finds new type 2 diabetes risk genes
February 1, 2021Single Amino Acid Change in NOVA1 Gene Altered Brain Development in Organoid Study

2020

October 7, 2020Charpentier and Doudna win 2020 Nobel Prize in Chemistrycrispr
October 1, 2020NCBI updates clinical reference for HEXA enzyme disordersgenomes
September 1, 2020Denisovan Y Chromosomes Split from Neanderthal-Human Lineage 700,000 Years Ago
August 19, 2020Cervical mucus may sort sperm by HLA compatibility, study finds
July 24, 2020King's College London team publishes polygenic risk score calculation guide in Nature Protocols
May 27, 2020Study catalogs loss-of-function variants across 141,456 human genomespopulation genomics
April 20, 2020Meta-analysis finds no overall link between MHC gene differences and human mate choice

2019

December 26, 2019Denisovan mitochondrial DNA fragment found in modern human nuclear genomes
October 21, 2019Prime editing writes new DNA sequences without cutting both strandscrispr
October 1, 2019Archaic Humans Passed Adaptive Gene Duplications to Melanesians
September 1, 2019ENIGMA Consortium Classifies 734 BRCA1 and BRCA2 Variantsgenomes
June 11, 20192019 study catalogs 571 genes separating modern humans from Neanderthals and other archaic hominins
May 24, 2019FDA approves Zolgensma gene therapy for infant SMAgene therapy
April 1, 2019Genetic score tied to weight gain from childhood to adulthood
March 7, 2019HLA gene algorithm predicts recurrent miscarriage risk
March 1, 2019Study finds MHC mate preference varies by population
March 1, 2019Neanderthal blood-clotting gene tied to survival in childbirth, study findsgenomes
February 25, 2019Study finds five genetic risk loci for autism
February 4, 2019Study links 102 gene variants to depression
January 29, 2019Study finds 351 genetic variants tied to morning preference in nearly 700,000 people
January 15, 2019One million parental lifespans analyzed to find genetic variants tied to longevity
January 1, 2019GWAS Catalog adds 284 summary statistics datasets and 6 billion variant trait statistics

2018

November 26, 2018Chinese scientist claims first genome-edited babies born this monthcrispr
October 13, 2018Gene Variant in Melatonin Receptor Tied to Morning-Person Trait
October 10, 2018UK Biobank releases genetic data on 500,000 participants
October 1, 2018Meta-analysis finds 3290 height variants and 941 BMI variants in 700000 Europeans
September 27, 2018Genetic risk score improved coronary prediction in diabetes trial
August 27, 2018Machine Learning Predictor Captures Most Heritable Height Variance Using 20,000 SNPs
August 13, 2018Genome-wide risk scores flag disease-prone groups without rare mutationspolygenic
July 30, 2018Study links 111 gene regions to atrial fibrillation
July 23, 2018Study finds 1,271 gene variants linked to educational attainmentpolygenic
February 19, 2018Stallion Sperm Counts Rise After Exposure to Mares with Different Immune Genes
January 22, 2018Male-biased genes in willow reproductive tissue evolve more slowly than female-biased counterparts