Myotis bat genomes show linked evolution of longevity and viral defense
Researchers generated near-complete genome assemblies and primary cell lines for eight Myotis bat species to trace the genetic basis of extreme lifespan variation and viral tolerance. The study, published in Nature, found genome-wide positive selection in proteins that interact with DNA viruses and elevated copy-number variation in genes that bind RNA viruses, a pattern not seen in other mammals. Ancient duplications of the immune gene EIF2AK2 segregate as trans-species polymorphisms across Myotis lineages. Primary cells from the long-lived Myotis lucifugus showed a distinct DNA damage response. Positive selection in cancer pathways correlated with species known for extended lifespans.
The work shows that bats' antiviral defenses and long lives share genetic roots, offering a comparison for mammalian aging research.
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