Mayo Clinic records reveal five distinct metabolic liver disease subtypes
Researchers analyzed Mayo Clinic electronic health records and found five subgroups of metabolic dysfunction-associated steatotic liver disease, each with different genetic and clinical profiles. The study, published in Nature Communications, used latent class analysis to identify the patterns. One subgroup is male-predominant and shows cardiorenal features. Another is female-predominant and linked to obesity and mood disorders. A third, called polygenic MASLD, has the lowest incidence of metabolic comorbidities and ischemic heart disease but the highest rate of liver transplant. That transplant risk appears driven in part by combinations of risk alleles in TM6SF2 and MBOAT7 together with protective variants in HSD17B13.
The subtypes may enable doctors to tailor treatment strategies for individual patients with metabolic liver disease.
Written by the Genomes desk from the primary source cited and linked above and checked against it. Research use only; not medical advice. Corrections: [email protected].