Diabetes subtypes traced to different genetic drivers
Researchers working from Lund University's ANDIS study, with replication in Finland's DIREVA and Botnia cohorts, ran genome-wide association and genetic risk score analysis on five previously identified type 2 diabetes subtypes. One finding stood out: the severe insulin-resistant subtype associated with a genetic risk score for fasting insulin, but not with TCF7L2 variants or insulin-secretion risk scores. A variant near the LRMDA gene, rs10824307, associated uniquely with mild obesity-related diabetes.
The results point to distinct genetic causes behind some diabetes subtypes, which could eventually shape more tailored research directions.
Written by the Genomes desk from the primary source cited and linked above and checked against it. Research use only; not medical advice. Corrections: [email protected].